Profile of Dr. Md. Mohasin

... Name Dr. Md. Mohasin
Designation Assistant Professor
Last Degree Ph.D (UK)
   

EDUCATION AND QUALIFICATIONS:

 

2014-Present :  PhD student in Dept. of Infection, Immunity and Cardiovascular Disease,    University of Sheffield, Sheffield, United Kingdom.

2009-2010:  MSc. secured First Class, 3rd position in Dept. of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh

2004-2008  : BSc. (Honours) secured First class, 1st position in the Dept. of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh

2003  :HSC in Science secured A grade Ramganj Government College, Lakshmipur, Bangladesh

2001: SSC in Science secured A grade Bhadur High School, Lakshmipur, Bangladesh

RESEARCH EXPERIENCE AND PROFESSIONAL POSITIONS

1. Research Student (December 2008-March 2010): My MSc. thesis title was “Antigen specific memory B-cell responses after oral cholera vaccination in adults”, submitted to the department of Biochemistry and Molecular Biology, Dhaka University (DU) for the partial fulfillment of Masters Degree. This research work has done in the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B). During thesis work, I became accustomed with different molecular, biochemical and immunological techniques such as multiplex Polymerase Chain Reaction (M-PCR), ELISPOT, ELISA, Western Blotting, SDS-PAGE, Vibriocidal assay, Flow Cytometry (FACS), mononuclear cell separation, Antibody in Lymphocyte Supernatant (ALS) and Cell Culture assays etc.

2. Research Officer (April 2010-Feb 2012): I joined as a Research Officer at the Immunology Laboratory, Centre for Vaccine Sciences, ICDDR,B. We investigated the adaptive immune responses after diarrheal infection and vaccination. We evaluated the antigen specific memory B cells against Vibrio cholerae and Enterotoxigenic E. coli antigens.

3. Faculty Member (March 2012- Present): I joined as a Lecturer in the department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh on 1st March, 2012.

4. Research Associate (Nov 2012- April 2013): I joined as a Research Associate in the department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. I took a leave for six months from University of Dhaka to take up this position. We assessed the immune responses of human oral ETEC vaccine, which was composed by genetically modified strains of Enterotoxigenic Escherichia coli (ETEC) and double mutant heat labile toxin as an adjuvant.

LIST OF PUBLICATIONS

  1. HIV gp120 in lungs of ART-treated individuals impairs alveolar macrophages responses to pneumococci. Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M, Dockrell DH. Am J Respir Crit Care Med. 2018 Jan 24. Doi: 10.1164/rccm.201708-1755OC. (Epub ahead of print)
  1. Impaired mitochondrial microbicidal responses in chronic obstructive pulmonary disease macrophages. Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LC, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH. Am J Respir Crit Care Med. 2017 Oct 1:196(7):845-855, doi: 10.1164/rccm.201608-1714OC.
  2. Assessment of physicochemical and biochemical qualities of tannery effluents of Hazaribagh, Dhaka, and comparison with non-tannery water samples. Laila N. Islam, Adua Rahman, Zimam Mahmud, A. H. M. Nurun Nabi, Mahmud Hossain, Mohasin M. International Journal of Environment, Volume-4, Issue-1, Dec-Feb 2014/15, page: 68-81
  3. Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera. Johnson RA, Uddin T, Aktar A, Mohasin M, Alam MM, Chowdhury F, Harris JB, LaRocque RC,Bufano M, Yu Y, Wu Y, Leung DT, Sarracino D, Krastins B, Charles RC, Xu P, Kováč P, Calderwood SB, Qadri F, Ryan ET. Clin Vaccine Immunol. 2012 Nov;19(11):1712-21. doi: 10.1128/CVI.00321-12. Epub 2012 Sep 19.
  1. Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide (LPS) are associated with protection against infection in household contacts of cholera patients in Bangladesh. Patel SM, Rahman MA, Mohasin M, Riyadh MA, Leung DT, Alam MM, Chowdhury F, Khan AI, Weil AA, Aktar A, Nazim, LaRocque RC, Ryan ET, Calderwood SB, Qadri F and Harris JB. Clin. Vaccine Immunol. 2012, 19(6):842-8. Epub 2012 April 18.
  1. Memory B cell and other immune responses in children receiving two doses of a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh. Leung DT, Rahman MA, Mohasin M, Patel SM, Aktar A, Khanam F,Uddin T, Riyadh MA, Saha A, Alam MM, Chowdhury F, Khan AI, Charles R, LaRocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Clin Vaccine Immunol. 2012 May;19(5):690-8. Epub 2012 Mar 21.
  1. Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh. Leung DT, Rahman MA, Mohasin M, Riyadh MA, Patel SM, Alam MM, Chowdhury F, Khan AI, Kalivoda EJ, Aktar A, Bhuiyan MS, LaRocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Clin Vaccine Immunol. 2011 Aug;18(8):1317-25.

TEACHING EXPERIENCE:

September 2014 to Present: Assistant Professor, at the department of Biochemistry and Molecular Biology, University of Dhaka.

March 2012- September 2014: I joined as a Lecturer at the department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh.

AWARDS AND SCHOLARSHIPS:

  1.  Dhaka University (DU) “Dean’s Award- 2007 for outstanding result on BSc(Hon’s) degree.
  2. DU’s award for obtaining first class first place in B. Sc. (Hon’s) examination-2007.
  3.  Bangladesh Science and Technology Ministry Grant award as an Associate Investigator-2012.
  4.  Johns Hopkins Bloomberg School of Public Health short term scholar grants as a Research Associate-2012.
  5.  Commonwealth PhD Scholarship 2014 for PhD studentship in University of Sheffield, United Kingdom.

RESEARCH INTEREST:

Streptococcus pneumoniae, the commonest commensal lung pathogen for community-acquired pneumonia. Macrophages are key effectors of innate immune responses but the precise microbicidal mechanisms used to control pneumococci are incompletely characterised. We have demonstrated that macrophages use mitochondrial reactive oxygen species (mROS) as a component of the microbicidal response and mROS are important in an apoptotic programme that contributes to intracellular bacteria killing. I believe mitochondrial dynamics (i.e. fission/fusion) also play indispensable role for the above mentioned mROS production beyond energy supply, which are recruited in phagolysosomes and underpinning to kill internalised pathogens in macrophages. But some intracellular pathogens (e.g. Mycobacterium tuberculosis) not only persist but also replicate in phagocytes. Therefore, it is essential to understand how internalised pathogens evade cellular innate immune responses as well as impinge stimulation of subsequent adaptive immune responses (e.g. T and B-cell responses). The latter component is essential for immune memory for persistent protection against pathogenic infection. My research interests lie broadly on mitochondrial metabolic phenotype as well as mitochondrial dynamics in response to intracellular bacteria, which could be the important elements of microbicidal response to internalised pathogens.

TEACHING EXPERIENCE:

September 2014 to Present: Assistant Professor, at the department of Biochemistry and Molecular Biology, University of Dhaka.

March 2012- September 2014: I joined as a Lecturer at the department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh.

 

 

 

 MD. MOHASIN

Assistant Professor(on study leave)

Department of Biochemistry and Molecular Biology

University of Dhaka

 

Current address:

PhD Student

Department of Infection and Immunity

University of Sheffield

Sheffield, South Yorkshire

Lu128, S10 2RX

United Kingdom

Contact No. +447914853318

E-mail: mmohasin1@sheffield.ac.uk

Alternative e-mail: mohasin@du.ac.bd

RESEARCH INTEREST:

Streptococcus pneumoniae, the commonest commensal lung pathogen for community-acquired pneumonia. Macrophages are key effectors of innate immune responses but the precise microbicidal mechanisms used to control pneumococci are incompletely characterised. We have demonstrated that macrophages use mitochondrial reactive oxygen species (mROS) as a component of the microbicidal response and mROS are important in an apoptotic programme that contributes to intracellular bacteria killing. I believe mitochondrial dynamics (i.e. fission/fusion) also play indispensable role for the above mentioned mROS production beyond energy supply, which are recruited in phagolysosomes and underpinning to kill internalised pathogens in macrophages. But some intracellular pathogens (e.g. Mycobacterium tuberculosis) not only persist but also replicate in phagocytes. Therefore, it is essential to understand how internalised pathogens evade cellular innate immune responses as well as impinge stimulation of subsequent adaptive immune responses (e.g. T and B-cell responses). The latter component is essential for immune memory for persistent protection against pathogenic infection. My research interests lie broadly on mitochondrial metabolic phenotype as well as mitochondrial dynamics in response to intracellular bacteria, which could be the important elements of microbicidal response to internalised pathogens.

 

RESEARCH EXPERIENCE AND PROFESSIONAL POSITIONS

 

1. Research Officer (April 2010-Feb 2012): I joined as a Research Officer at the Immunology Laboratory, Centre for Vaccine Sciences, ICDDR,B. My main responsibilities were to track out innate and adaptive immune responses after diarrheal infection and vaccination. Through my research works, our team tracked some antigen specific memory B cells againstVibriocholerae and Enterotoxigenic E. coli which might contribute for long lasting protection.

 

2. Faculty Member (March 2012- Present): I joined as a Lecturer at the department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh on 1st March 2012. I taught both theory and practical coursesat undergraduate and MS level.

 

3. Research Associate (Nov 2012- April 2013): I joined as a Research Associate at the department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. I took a leave for six months from University of Dhaka to take up this position. Here I have worked on a ETEC vaccine which made by genetically modified strains of Enterotoxigenic Escherichia coli (ETEC) and double mutant heat labile toxin adjuvant, quantify its immune responses especially ETEC specific memory B cell by the ELISPOT technique.

 

Education and Qualifications:

 

2014-Present         PhD student in Dept. of Infection, Immunity and Cardiovascular Disease,

University of Sheffield, Sheffield, United Kingdom

2009-2010                MSc. secured First Class, 3rd position in Dept. of Biochemistry and Molecular Biology,     University of Dhaka, Dhaka, Bangladesh

 

2004-2008                  BSc.(Honours) secured First clas, 1st position in Dept. of Biochemistry and Molecular Biology,University of Dhaka, Dhaka, Bangladesh

2003                            HSC in SciencesecuredA grade

Ramganj Government College, Lakshmipur, Bangladesh

 

2001                SSC in SciencesecuredA grade

Bhadur High School, Lakshmipur, Bangladesh

 

 

LIST OF PUBLICATIONS

  1. HIV gp120 in lungs of ART-treated individuals impairs alveolar macrophages responses to pneumococci. Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M, Dockrell DH. Am J Respir Crit Care Med. 2018 Jan 24. Doi: 10.1164/rccm.201708-1755OC. (Epub ahead of print)
  1. Impaired mitochondrial microbicidal responses in chronic obstructive pulmonary disease macrophages. Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LC, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH. Am J Respir Crit Care Med. 2017 Oct 1:196(7):845-855, doi: 10.1164/rccm.201608-1714OC.
  2. Assessment of physicochemical and biochemical qualities of tannery effluents of Hazaribagh, Dhaka, and comparison with non-tannery water samples. Laila N. Islam, Adua Rahman, Zimam Mahmud, A. H. M. Nurun Nabi, Mahmud Hossain, Mohasin M. International Journal of Environment, Volume-4, Issue-1, Dec-Feb 2014/15, page: 68-81
  3. Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera. Johnson RA, Uddin T, Aktar A, Mohasin M, Alam MM, Chowdhury F, Harris JB, LaRocque RC,Bufano M, Yu Y, Wu Y, Leung DT, Sarracino D, Krastins B, Charles RC, Xu P, Kováč P, Calderwood SB, Qadri F, Ryan ET. Clin Vaccine Immunol. 2012 Nov;19(11):1712-21. doi: 10.1128/CVI.00321-12. Epub 2012 Sep 19.
  1. Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide (LPS) are associated with protection against infection in household contacts of cholera patients in Bangladesh. Patel SM, Rahman MA, Mohasin M, Riyadh MA, Leung DT, Alam MM, Chowdhury F, Khan AI, Weil AA, Aktar A, Nazim, LaRocque RC, Ryan ET, Calderwood SB, Qadri F and Harris JB. Clin. Vaccine Immunol. 2012, 19(6):842-8. Epub 2012 April 18.
  1. Memory B cell and other immune responses in children receiving two doses of a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh. Leung DT, Rahman MA, Mohasin M, Patel SM, Aktar A, Khanam F,Uddin T, Riyadh MA, Saha A, Alam MM, Chowdhury F, Khan AI, Charles R, LaRocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Clin Vaccine Immunol. 2012 May;19(5):690-8. Epub 2012 Mar 21.
  1. Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh. Leung DT, Rahman MA, Mohasin M, Riyadh MA, Patel SM, Alam MM, Chowdhury F, Khan AI, Kalivoda EJ, Aktar A, Bhuiyan MS, LaRocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Clin Vaccine Immunol. 2011 Aug;18(8):1317-25.