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Details of Md. Ismail Hosen


Curriculum Vitae of Md. Ismail Hosen, PhD

 

NAME

 

Hosen, Md Ismail

ismail.hosen@du.ac.bd

 

EDUCATION

Institution and Location

Degree

Year

 Field of study

German Cancer Research Center (DKFZ), University of Heidelberg, Heidelberg, Germany

PhD

2015

Molecular Genetic Epidemiology

Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

MSc

2009

Biochemistry and Molecular Biology

Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

BSc

2008

Biochemistry and Molecular Biology

 

PERSONAL STATEMENT

The rapid advancement of the functional genomics field has enabled us to see with wonder that how the non-coding part of our genome is leaving its fingerprint in regulation. The cancer cells are exploiting these unjustly called ' junk DNA ' to its own advantage. These interesting phenomena fascinate me to involve myself in the area of functional genomics and contribute to the development of basic understanding in this field. During my PhD at the German Cancer Research Center (DKFZ), I have worked on telomere biology and role of germline and somatic mutations in TERT gene and risk of different cancer. We have already shown the risk modifying effect of a polymorphism in the TERT promoter in bladder cancer, kidney cancer and glioma in European population. Our functional analysis using different cell lines, showed that the rs2853669 polymorphism located at a Ets transcription factor binding motif in the TERT promoter acts as a risk modifier. We have also studies of telomere length in different cancer as evidenced by our recent publications. I have experience in working in the field of immunology and vaccine sciences, where I used flow cytometric and ELISA/ELISPOT based methods to characterize T- and B-cell responses in diarrheal patients and vaccine recipients. Moreover, I also worked on some rare genetic polymorphisms and risk of childhood ALL in European population. 

SELECTED PEER-REVIEWED PUBLICATIONS

1. Hosen I, Rachakonda PS, Heidenreich B, de Verdier PJ, Ryk C, Steineck G, Hemminki K, Kumar R.Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer.Int J Cancer. 2015 Oct 1;137(7):1621-9. doi: 10.1002/ijc.29526. Epub 2015 Apr 7.

2. Hosen I, Rachakonda PS, Heidenreich B, Sitaram RT, Ljungberg B, Roos G, Hemminki K, Kumar R. TERT promoter mutations in clear cell renal cell carcinoma. International journal of cancer. Journal international du cancer 2014.

3. Simon M, Hosen I, Gousias K, Rachakonda S, Heidenreich B, Gessi M, Schramm J, Hemminki K, Waha A, Kumar R. TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas. Neuro-oncology 2014.

4. Hosen I, Tanmoy AM, Mahbuba DA, Salma U, Nazim M, Islam MT, Akhteruzzaman S. Application of a subtractive genomics approach for in silico identification and characterization of novel drug targets in Mycobacterium tuberculosis F11. Interdisciplinary sciences, computational life sciences 2014;6:48-56.

5. Rachakonda PS, Hosen I, de Verdier PJ, Fallah M, Heidenreich B, Ryk C, Wiklund NP, Steineck G, Schadendorf D, Hemminki K, Kumar R. TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism. PNAS 2013;110:17426-31.

6. Heidenreich B, Rachakonda PS, Hosen I, Volz F, Hemminki K, Weyerbrock A, Kumar R.TERT promoter mutations and telomere length in adult malignant gliomas and recurrences.Oncotarget. 2015 Apr 30;6(12):10617-33.TERT promoter mutations and telomere length in adult malignant gliomas and recurrences. 

7. Hasan M, Momtaz P, Hosen I, Das SA, Akhteruzzaman S. Population genetics of 17 Y-chromosomal STRs loci in Garo and Santal tribal populations in Bangladesh. International journal of legal medicine 2014.

8. Islam MR, Hosen I, Zaman A, Islam MO. Structural, functional and molecular docking study to characterize GMI1 from Arabidopsis thaliana. Interdisciplinary sciences, computational life sciences 2013;5:13-22.

9. Davies JR, Field S, Randerson-Moor J, Harland M, Kumar R, Anic GM, Nagore E, Hansson J, Höiom V, Jönsson G, Gruis NA, Park JY, Guan J, SivaramakrishnaRachakonda P, Wendt J, Pjanova D, Puig S, Schadendorf D, Okamoto I, Olsson H, Affleck P, García-Casado Z, Puig-Butille JA, Stratigos AJ, Kodela E, Donina S, Sucker A, Hosen I, Egan KM, Barrett JH, van Doorn R, Bishop DT, Newton-Bishop J. An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma: a BioGenoMEL study. Pigment cell & melanoma research 2014;27:234-43.

10. Alam MM, Arifuzzaman M, Ahmad SM, Hosen I, Rahman MA, Rashu R, Sheikh A, Ryan ET, Calderwood SB, Qadri F. Study of avidity of antigen-specific antibody as a means of understanding development of long-term immunological memory after Vibrio cholerae O1 infection. Clinical and vaccine immunology: CVI 2013;20:17-23.

11. Arifuzzaman M, Rashu R, Leung DT, Hosen I, Bhuiyan TR, Bhuiyan MS, Rahman MA, Khanam F, Saha A, Charles RC, LaRocque RC, Weil AA, et al. Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera. Clinical and vaccine immunology: CVI 2012;19:1304-11.

12. Taibur Rahman, Ismail Hosen, M. M. Towhidul Islam, Hossain Uddin Shekhar. Oxidative stress and human health. Advances in Bioscience and Biotechnology, 2012, 3, 997-1019

13. Taibur Rahman, Ismail Hosen, Sajib Chakraborty. A Rapid Glimpse on Typhoid Fever: An Updated MiniReview. Journal of Life Medicine, Vol. 1, Issue 3, Oct  2013, Pages 83-92.

14. Denisova E, Heidenreich B, Nagore E, Rachakonda PS, Hosen I, Akrap I, Traves V, García-Casado  Z, López-Guerrero JA, Requena C, Sanmartin O, Serra-Guillén C, Llombart B, Guillén C, Ferrando J, Gimeno E, Nordheim A, Hemminki K, Kumar R. Frequent DPH3 promoter mutations in skin cancers. Oncotarget. 2015 Sep 21. [Epub ahead of print].

15. Jobaida Akther, Akio Ebihara, Tsutomu Nakagawa, Laila N. Islam, Fumiaki Suzuki, Md. Ismail Hosen, Mahmud Hossain, and A. H. M. Nurun Nabi. “Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls,” BioMed Research International, vol. 2016, Article ID 6973057, 8 pages, 2016. doi:10.1155/2016/6973057.

16. Vijayakrishnan J, Kumar R, Henrion MY, Moorman AV, Rachakonda PS, Hosen I, da Silva Filho MI, Holroyd A, Dobbins SE, Koehler R, Thomsen H, Irving JA, Allan JM, Lightfoot T, Roman E, Kinsey SE,, Sheridan E, Thompson PD, Hoffmann P,,, Nöthen MM,, Heilmann-Heimbach S,, Karl-Heinz J,, Greaves M, Harrison CJ, Bartram CR, Schrappe M, Stanulla M, Hemminki K,, Houlston RS. Leukemia. 2016 Oct 3. doi: 10.1038/leu.2016.271. [Epub ahead of print]. A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1.

 

PROFESSIONAL EXPERTISE

1. Able to analyze the genetic variation data using the ENCODE, Regulome DB, Haploreg, Haploview and other bioinformatics databases and tracks.

2. Skilled in basic molecular biology techniques such as Cloning, Real time PCR, Sanger sequencing, Pyrosequencing, Genotyping, Cell culture etc.

3. Familiar with SAS for analyzing data.

POSITIONS AND EMPLOYMENT              

02/2016 - Present:      Assistant Professor, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

03/2012- 02/2016:       Lecturer, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh. (Was on study leave from 10/2012 to 09/2015)

10/2012- 09/2015:       Doctoral Graduate Student, Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

06/2011 – 02/2012:     Research Officer, Immunology laboratory, Centre for Vaccine Sciences, ICDDR,B,  Dhaka, Bangladesh

11/2009 – 05/2011:     Research Fellow as a MSc thesis student, Immunology laboratory, Centre for Vaccine Sciences, ICDDR,B,  Dhaka, Bangladesh

TRAINING AND WORKSHOP

  • Workshop on “ENSEMBL Genome browser” at the German Cancer Research Center (2015).
  • Training on “Pyrosequencing using the Pyromark Q24” at the German Cancer Research Center (2014).
  • Data analysis through tools of forensic science and population genetics at the University of Dhaka (2012).

 

HONORS

2009                            Awarded for the Deans Award from the University of Dhaka for excellent performance in Bachelor degree under the Biological faculty.

2015                            Selected for Kamal Uddin Ahmed Gold Medal awards, from the University of Dhaka for outstanding academic results in MSc study (exam of 2009).

GRANTS AWARDED

1.  Awarded grants as a Co-PI by the ministry of Science and Technology, Bangladesh in 2013.

Title of the project: Application of a subtractive genomics approach for in silico identification of drug targets.

2.  Awarded grants as a Co-PI by the ministry of Science and Technology, Bangladesh in 2015.

Title of the project: Oxidative stress and antioxidant defense system of heavy metal tolerant plants from polluted soils of industrial area of Dhaka city.