Profile of Dr. Md. Ismail Hosen (on study leave)

... Name Dr. Md. Ismail Hosen (on study leave)
Designation Assistant Professor
Last Degree PhD (German Cancer Research Center, Heidelberg, Germany)
   

 

EDUCATION:

Institution and Location

Degree

Year

 Field of study

German Cancer Research Center (DKFZ), University of Heidelberg,

Heidelberg, Germany

PhD

2015

Molecular Genetic Epidemiology

Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

MSc

2009

Biochemistry and Molecular Biology

Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

BSc

2008

Biochemistry and Molecular Biology

PROFESSIONAL EXPERTISE:

  1. Able to analyze the genetic variation data using the ENCODE, Regulome DB, Haploreg, Haploviewand other bioinformatics databases and tracks.
  2. Experience in NGS-based laboratory activities (used in the ion-proton system).
  3. Skilled in basic molecular biology techniques such as Cloning, Real time PCR, Sanger sequencing, Pyrosequencing, Genotyping, Cell culture etc.
  4. Familiar with SAS for analyzing data.
  5. Functional genomics study.

SELECTED PEER-REVIEWED PUBLICATIONS:

2018

  1. Md. Ismail Hosen, Md. Mahamud Hasan, Tania Hossain, Ashish K. Majumder, Abu Sufian, PiluMomtaz and Sharif Akhteruzzaman.  STR Data for the AmpFlSTR SGM Plus Loci From Three Ethnic Populations of Bangladesh and Their Genetic Affinities With Other Populations. Bioresearch Communications, January 2018, Volume 4, issue 1, Page: 487-493.
  2. Hossain, R., Yasmin, T., Hosen, M.I., and Nabi, A. (2018). In silico identification of potential epitopes present in human adenovirus proteins for vaccine design and of putative drugs for treatment against viral infection. Journal of immunological methods 455, 55-70.

 

2017

  1. Heidenreich, B., Denisova, E., Rachakonda, S., Sanmartin, O., Dereani, T., Hosen, I., Nagore, E., and Kumar, R. (2017). Genetic alterations in seborrheic keratoses. Oncotarget 8, 36639-36649.
  1. Hossain, T., Kamruzzaman, M., Choudhury, T.Z., Mahmood, H.N., Nabi, A., and Hosen, M.I. (2017). Application of the Subtractive Genomics and Molecular Docking Analysis for the Identification of Novel Putative Drug Targets against Salmonella enterica subsp. enterica serovar Poona. BioMed research international 2017, 3783714.
  1. Sufian, A., Hosen, M.I., Fatema, K., Hossain, T., Hasan, M.M., Mazumder, A.K., and Akhteruzzaman, S. (2017). Genetic diversity study on 12 X-STR loci of investigator(R) Argus X STR kit in Bangladeshi population. International journal of legal medicine 131, 963-965.
  1. Vijayakrishnan, J., Kumar, R., Henrion, M.Y., Moorman, A.V., Rachakonda, P.S., Hosen, I., da Silva Filho, M.I., Holroyd, A., Dobbins, S.E., Koehler, R., et al. (2017). A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1. Leukemia 31, 573-579.

 

2016

  1. Akther, J., Ebihara, A., Nakagawa, T., Islam, L.N., Suzuki, F., Hosen, M.I., Hossain, M., and Nabi, A.H. (2016). Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls. BioMed research international 2016, 6973057.

 

2015

  1. Denisova, E., Heidenreich, B., Nagore, E., Rachakonda, P.S., Hosen, I., Akrap, I., Traves, V., Garcia-Casado, Z., Lopez-Guerrero, J.A., Requena, C., et al. (2015). Frequent DPH3 promoter mutations in skin cancers. Oncotarget 6, 35922-35930.
  1. Hasan, M., Momtaz, P., Hosen, I., Das, S.A., and Akhteruzzaman, S. (2015). Population genetics of 17 Y-chromosomal STRs loci in Garo and Santal tribal populations in Bangladesh. International journal of legal medicine 129, 251-252.
  1. Heidenreich, B., Rachakonda, P.S., Hosen, I., Volz, F., Hemminki, K., Weyerbrock, A., and Kumar, R. (2015). TERT promoter mutations and telomere length in adult malignant gliomas and recurrences. Oncotarget 6, 10617-10633.
  1. Hosen, I., Rachakonda, P.S., Heidenreich, B., de Verdier, P.J., Ryk, C., Steineck, G., Hemminki, K., and Kumar, R. (2015a). Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer. International journal of cancer 137, 1621-1629.
  1. Hosen, I., Rachakonda, P.S., Heidenreich, B., Sitaram, R.T., Ljungberg, B., Roos, G., Hemminki, K., and Kumar, R. (2015b). TERT promoter mutations in clear cell renal cell carcinoma. International journal of cancer 136, 2448-2452.
  1. Simon, M., Hosen, I., Gousias, K., Rachakonda, S., Heidenreich, B., Gessi, M., Schramm, J., Hemminki, K., Waha, A., and Kumar, R. (2015). TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas. Neuro-oncology 17, 45-52.

 

2014

  1. Davies, J.R., Field, S., Randerson-Moor, J., Harland, M., Kumar, R., Anic, G.M., Nagore, E., Hansson, J., Hoiom, V., Hosen, MI, Jonsson, G., et al. (2014). An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma: a BioGenoMEL study. Pigment cell & melanoma research 27, 234-243.
  1. Hosen, M.I., Tanmoy, A.M., Mahbuba, D.A., Salma, U., Nazim, M., Islam, M.T., and Akhteruzzaman, S. (2014). Application of a subtractive genomics approach for in silico identification and characterization of novel drug targets in Mycobacterium tuberculosis F11. Interdisciplinary sciences, computational life sciences 6, 48-56.

 

2013

  1. Akhteruzzaman, S., Das, S.A., Hosen, I., and Ferdous, A. (2013). Genetic polymorphism of 30 InDel markers for forensic use in Bangladeshi population. Forensic Science International: Genetics Supplement Series 4, e348-e349.
  2. Alam, M.M., Arifuzzaman, M., Ahmad, S.M., Hosen, M.I., Rahman, M.A., Rashu, R., Sheikh, A., Ryan, E.T., Calderwood, S.B., and Qadri, F. (2013). Study of avidity of antigen-specific antibody as a means of understanding development of long-term immunological memory after Vibrio cholerae O1 infection. Clinical and vaccine immunology : CVI 20, 17-23.
  1. Islam, M.R., Hosen, M.I., Zaman, A., and Islam, M.O. (2013). Structural, functional and molecular docking study to characterize GMI1 from Arabidopsis thaliana. Interdisciplinary sciences, computational life sciences 5, 13-22.
  1. Taibur Rahman, Ismail Hosen, Sajib Chakraborty. A Rapid Glimpse on Typhoid Fever: An Updated MiniReview. Journal of Life Medicine, Vol. 1, Issue 3, Oct  2013, Pages 83-92.
  1. Rachakonda, P.S., Hosen, I., de Verdier, P.J., Fallah, M., Heidenreich, B., Ryk, C., Wiklund, N.P., Steineck, G., Schadendorf, D., Hemminki, K., et al. (2013). TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism. Proceedings of the National Academy of Sciences of the United States of America 110, 17426-17431.

2012

  1. Arifuzzaman, M., Rashu, R., Leung, D.T., Hosen, M.I.,Bhuiyan, T.R., Bhuiyan, M.S., Rahman, M.A., Khanam, F., Saha, A., Charles, R.C., et al. (2012). Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera. Clinical and vaccine immunology : CVI 19, 1304-1311.
  1. Rahman, T., Hosen, I., Islam, M.M.T., and Shekhar, H.U. (2012). Oxidative stress and human health. Advances in Bioscience and Biotechnology Vol.03No.07, 23.

POSITIONS AND EMPLOYMENT:      

02/2016 - Present:      Assistant Professor, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

03/2012- 02/2016:       Lecturer, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh. (Was on study leave from 10/2012 to 09/2015)

10/2012- 09/2015:       Doctoral Graduate Student, Department ofMolecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

06/2011 – 02/2012:     Research Officer, Immunology laboratory, Centre for Vaccine Sciences, ICDDR,B,  Dhaka, Bangladesh

11/2009 – 05/2011:     Research Fellow as a MSc thesis student, Immunology laboratory, Centre for Vaccine Sciences, ICDDR,B,  Dhaka, Bangladesh

 

HONORS and AWARDS:

2009:  Awarded for the Deans Award from the University of Dhaka for excellent performance in Bachelor degree under the Biological faculty.

2015: Selected for Kamal Uddin Ahmed Gold Medal awards, from the University of Dhaka for outstanding academic results in MSc study (exam of 2009).

RESEARCH GRANTS AWARDED:

1.  Awarded grants as a Co-PI by the ministry of Science and Technology, Bangladesh in 2013. Title of the project: Application of a subtractive genomics approach for in silico identification of drug targets.

2.  Awarded grants as a Co-PI by the ministry of Science and Technology, Bangladesh in 2015. Title of the project: Oxidative stress and antioxidant defense system of heavy metal tolerant plants from polluted soils of industrial area of Dhaka city.

STATEMENT OF RESEACH INTERESTS:

The rapid advancement of the functional genomics field has enabled us to see with wonder that how the non-coding part of our genome; besides the coding region; is leaving its fingerprint in regulation. The cancer cells are exploiting these unjustly called 'junk DNA' to its own advantage. These interesting phenomena fascinate me to involve myself in the area of functional genomics and contribute to the development of basic understanding in this field. During my PhD at the German Cancer Research Center (DKFZ), I have worked on telomere biology and role of germline and somatic mutations in TERT gene and risk of different cancer. We have already shown the risk modifying effect of a polymorphism in the TERT promoter in bladder cancer, kidney cancer and glioma in European population. Our functional analysis using different cell lines showed that the rs2853669 polymorphism located at anEts transcription factor binding motif in the TERT promoter acts as a risk modifier for patient survival and tumor recurrence in bladder cancer. We have also studies of telomere length in different cancer as evidenced by our recent publications. I have also experience in working in the field of immunology and vaccine sciences, where I used flow cytometric and ELISA/ELISPOT based methods to characterize T- and B-cell responses in diarrheal patients and vaccine recipients. Moreover, I also worked on some rare genetic polymorphisms and risk of childhood ALL in European population. Currently, we are preparing the manuscripts for those findings. Currently, I am recruiting Bangladeshi children diagnosed with ALL; to study their genetic impact and we have already started work on genetic polymorphism in other cancers including bladder cancer in Bangladeshi population.

My research interests lie broadly in the area of functional genomics of cancer. Specifically, I am eager to dissect the impact of rare germline genetic polymorphisms in conferring risk of diverse cancer. Besides, I also have a plan to work on the GWAS and NGS based study to find and explore the contribution of novel somatic and/or germline mutations in cancer. These are the plans to achieve the goals of efficiently implementing personalized genomics in the management of cancer.

POSITIONS AND EMPLOYMENT:      

02/2016 - Present:      Assistant Professor, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

03/2012- 02/2016:       Lecturer, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh. (Was on study leave from 10/2012 to 09/2015)

10/2012- 09/2015:       Doctoral Graduate Student, Department ofMolecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

06/2011 – 02/2012:     Research Officer, Immunology laboratory, Centre for Vaccine Sciences, ICDDR,B,  Dhaka, Bangladesh

11/2009 – 05/2011:     Research Fellow as a MSc thesis student, Immunology laboratory, Centre for Vaccine Sciences, ICDDR,B,  Dhaka, Bangladesh

Curriculum Vitae of Md. Ismail Hosen, PhD

 

NAME

 

Hosen, Md Ismail

ismail.hosen@du.ac.bd

Ismail Hosen

ORCID ID: https://orcid.org/0000-0003-0862-7206

 

EDUCATION

Institution and Location

Degree

Year

 Field of study

German Cancer Research Center (DKFZ), University of Heidelberg,

Heidelberg, Germany

PhD

2015

Molecular Genetic Epidemiology

Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

MSc

2009

Biochemistry and Molecular Biology

Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

BSc

2008

Biochemistry and Molecular Biology

 

 

PROFESSIONAL EXPERTISE

  1. Able to analyze the genetic variation data using the ENCODE, Regulome DB, Haploreg, Haploviewand other bioinformatics databases and tracks.
  2. Experience in NGS-based laboratory activities (used in the ion-proton system).
  3. Skilled in basic molecular biology techniques such as Cloning, Real time PCR, Sanger sequencing, Pyrosequencing, Genotyping, Cell culture etc.
  4. Familiar with SAS for analyzing data.
  5. Functional genomics study.

 

POSITIONS AND EMPLOYMENT              

02/2016 - Present:      Assistant Professor, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

03/2012- 02/2016:       Lecturer, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh. (Was on study leave from 10/2012 to 09/2015)

10/2012- 09/2015:       Doctoral Graduate Student, Department ofMolecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

06/2011 – 02/2012:     Research Officer, Immunology laboratory, Centre for Vaccine Sciences, ICDDR,B,  Dhaka, Bangladesh

11/2009 – 05/2011:     Research Fellow as a MSc thesis student, Immunology laboratory, Centre for Vaccine Sciences, ICDDR,B,  Dhaka, Bangladesh

TRAINING AND WORKSHOP

  • Workshop on “ENSEMBL Genome browser” at the German Cancer Research Center (2015).
  • Training on “Pyrosequencing using the Pyromark Q24” at the German Cancer Research Center (2014).
  • Data analysis through tools of forensic science and population genetics at the University of Dhaka (2012).

 

HONORS and AWARDS

2009                            Awarded for the Deans Award from the University of Dhaka for excellent performance in Bachelor degree under the Biological faculty.

2015                            Selected for Kamal Uddin Ahmed Gold Medal awards, from the University of Dhaka for outstanding academic results in MSc study (exam of 2009).

RESEARCH GRANTS AWARDED

1.  Awarded grants as a Co-PI by the ministry of Science and Technology, Bangladesh in 2013.

Title of the project: Application of a subtractive genomics approach for in silico identification of drug targets.

2.  Awarded grants as a Co-PI by the ministry of Science and Technology, Bangladesh in 2015.

Title of the project: Oxidative stress and antioxidant defense system of heavy metal tolerant plants from polluted soils of industrial area of Dhaka city.

 

SELECTED PEER-REVIEWED PUBLICATIONS

2018

  1. Md. Ismail Hosen, Md. Mahamud Hasan, Tania Hossain, Ashish K. Majumder, Abu Sufian, PiluMomtaz and Sharif Akhteruzzaman.  STR Data for the AmpFlSTR SGM Plus Loci From Three Ethnic Populations of Bangladesh and Their Genetic Affinities With Other Populations. Bioresearch Communications, January 2018, Volume 4, issue 1, Page: 487-493.
  2. Hossain, R., Yasmin, T., Hosen, M.I., and Nabi, A. (2018). In silico identification of potential epitopes present in human adenovirus proteins for vaccine design and of putative drugs for treatment against viral infection. Journal of immunological methods 455, 55-70.

 

2017

  1. Heidenreich, B., Denisova, E., Rachakonda, S., Sanmartin, O., Dereani, T., Hosen, I., Nagore, E., and Kumar, R. (2017). Genetic alterations in seborrheic keratoses. Oncotarget 8, 36639-36649.
  1. Hossain, T., Kamruzzaman, M., Choudhury, T.Z., Mahmood, H.N., Nabi, A., and Hosen, M.I. (2017). Application of the Subtractive Genomics and Molecular Docking Analysis for the Identification of Novel Putative Drug Targets against Salmonella enterica subsp. enterica serovar Poona. BioMed research international 2017, 3783714.
  1. Sufian, A., Hosen, M.I., Fatema, K., Hossain, T., Hasan, M.M., Mazumder, A.K., and Akhteruzzaman, S. (2017). Genetic diversity study on 12 X-STR loci of investigator(R) Argus X STR kit in Bangladeshi population. International journal of legal medicine 131, 963-965.
  1. Vijayakrishnan, J., Kumar, R., Henrion, M.Y., Moorman, A.V., Rachakonda, P.S., Hosen, I., da Silva Filho, M.I., Holroyd, A., Dobbins, S.E., Koehler, R., et al. (2017). A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1. Leukemia 31, 573-579.

 

2016

  1. Akther, J., Ebihara, A., Nakagawa, T., Islam, L.N., Suzuki, F., Hosen, M.I., Hossain, M., and Nabi, A.H. (2016). Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls. BioMed research international 2016, 6973057.

2015

  1. Denisova, E., Heidenreich, B., Nagore, E., Rachakonda, P.S., Hosen, I., Akrap, I., Traves, V., Garcia-Casado, Z., Lopez-Guerrero, J.A., Requena, C., et al. (2015). Frequent DPH3 promoter mutations in skin cancers. Oncotarget 6, 35922-35930.
  1. Hasan, M., Momtaz, P., Hosen, I., Das, S.A., and Akhteruzzaman, S. (2015). Population genetics of 17 Y-chromosomal STRs loci in Garo and Santal tribal populations in Bangladesh. International journal of legal medicine 129, 251-252.
  1. Heidenreich, B., Rachakonda, P.S., Hosen, I., Volz, F., Hemminki, K., Weyerbrock, A., and Kumar, R. (2015). TERT promoter mutations and telomere length in adult malignant gliomas and recurrences. Oncotarget 6, 10617-10633.
  1. Hosen, I., Rachakonda, P.S., Heidenreich, B., de Verdier, P.J., Ryk, C., Steineck, G., Hemminki, K., and Kumar, R. (2015a). Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer. International journal of cancer 137, 1621-1629.
  1. Hosen, I., Rachakonda, P.S., Heidenreich, B., Sitaram, R.T., Ljungberg, B., Roos, G., Hemminki, K., and Kumar, R. (2015b). TERT promoter mutations in clear cell renal cell carcinoma. International journal of cancer 136, 2448-2452.
  1. Simon, M., Hosen, I., Gousias, K., Rachakonda, S., Heidenreich, B., Gessi, M., Schramm, J., Hemminki, K., Waha, A., and Kumar, R. (2015). TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas. Neuro-oncology 17, 45-52.

 

2014

  1. Davies, J.R., Field, S., Randerson-Moor, J., Harland, M., Kumar, R., Anic, G.M., Nagore, E., Hansson, J., Hoiom, V., Hosen, MI, Jonsson, G., et al. (2014). An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma: a BioGenoMEL study. Pigment cell & melanoma research 27, 234-243.
  1. Hosen, M.I., Tanmoy, A.M., Mahbuba, D.A., Salma, U., Nazim, M., Islam, M.T., and Akhteruzzaman, S. (2014). Application of a subtractive genomics approach for in silico identification and characterization of novel drug targets in Mycobacterium tuberculosis F11. Interdisciplinary sciences, computational life sciences 6, 48-56.

2013

  1. Akhteruzzaman, S., Das, S.A., Hosen, I., and Ferdous, A. (2013). Genetic polymorphism of 30 InDel markers for forensic use in Bangladeshi population. Forensic Science International: Genetics Supplement Series 4, e348-e349.
  2. Alam, M.M., Arifuzzaman, M., Ahmad, S.M., Hosen, M.I., Rahman, M.A., Rashu, R., Sheikh, A., Ryan, E.T., Calderwood, S.B., and Qadri, F. (2013). Study of avidity of antigen-specific antibody as a means of understanding development of long-term immunological memory after Vibrio cholerae O1 infection. Clinical and vaccine immunology : CVI 20, 17-23.
  1. Islam, M.R., Hosen, M.I., Zaman, A., and Islam, M.O. (2013). Structural, functional and molecular docking study to characterize GMI1 from Arabidopsis thaliana. Interdisciplinary sciences, computational life sciences 5, 13-22.
  1. Taibur Rahman, Ismail Hosen, Sajib Chakraborty. A Rapid Glimpse on Typhoid Fever: An Updated MiniReview. Journal of Life Medicine, Vol. 1, Issue 3, Oct  2013, Pages 83-92.
  1. Rachakonda, P.S., Hosen, I., de Verdier, P.J., Fallah, M., Heidenreich, B., Ryk, C., Wiklund, N.P., Steineck, G., Schadendorf, D., Hemminki, K., et al. (2013). TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism. Proceedings of the National Academy of Sciences of the United States of America 110, 17426-17431.

2012

  1. Arifuzzaman, M., Rashu, R., Leung, D.T., Hosen, M.I.,Bhuiyan, T.R., Bhuiyan, M.S., Rahman, M.A., Khanam, F., Saha, A., Charles, R.C., et al. (2012). Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera. Clinical and vaccine immunology : CVI 19, 1304-1311.
  1. Rahman, T., Hosen, I., Islam, M.M.T., and Shekhar, H.U. (2012). Oxidative stress and human health. Advances in Bioscience and Biotechnology Vol.03No.07, 23.

 

STATEMENT OF RESEACH INTERESTS

The rapid advancement of the functional genomics field has enabled us to see with wonder that how the non-coding part of our genome; besides the coding region; is leaving its fingerprint in regulation. The cancer cells are exploiting these unjustly called 'junk DNA' to its own advantage. These interesting phenomena fascinate me to involve myself in the area of functional genomics and contribute to the development of basic understanding in this field. During my PhD at the German Cancer Research Center (DKFZ), I have worked on telomere biology and role of germline and somatic mutations in TERT gene and risk of different cancer. We have already shown the risk modifying effect of a polymorphism in the TERT promoter in bladder cancer, kidney cancer and glioma in European population. Our functional analysis using different cell lines showed that the rs2853669 polymorphism located at anEts transcription factor binding motif in the TERT promoter acts as a risk modifier for patient survival and tumor recurrence in bladder cancer. We have also studies of telomere length in different cancer as evidenced by our recent publications. I have also experience in working in the field of immunology and vaccine sciences, where I used flow cytometric and ELISA/ELISPOT based methods to characterize T- and B-cell responses in diarrheal patients and vaccine recipients. Moreover, I also worked on some rare genetic polymorphisms and risk of childhood ALL in European population. Currently, we are preparing the manuscripts for those findings. Currently, I am recruiting Bangladeshi children diagnosed with ALL; to study their genetic impact and we have already started work on genetic polymorphism in other cancers including bladder cancer in Bangladeshi population.

My research interests lie broadly in the area of functional genomics of cancer. Specifically, I am eager to dissect the impact of rare germline genetic polymorphisms in conferring risk of diverse cancer. Besides, I also have a plan to work on the GWAS and NGS based study to find and explore the contribution of novel somatic and/or germline mutations in cancer. These are the plans to achieve the goals of efficiently implementing personalized genomics in the management of cancer.