Profile of Dr. Nazmul Qais

... Name Dr. Nazmul Qais
Designation Professor
Last Degree B.Pharm., M.Pharm., Ph.D.
   

1977 -1980 :     Department of Pharmacy, University of Dhaka, Bangladesh

                         Degree obtained : Bachelor of Pharmacy (Honours)

                         Major courses : Organic Pharmacy, Inorganic Pharmacy, Physical Pharmacy,

                         Medicinal Chemistry, Physiology, Pharmacology, Microbiology and Pharmaceutics.

1980-1981 :      Department of Pharmacy, University of Dhaka, Bangladesh

                         Degree obtained : Master of Pharmacy*

                         Major courses : Medicinal  Chemistry, Pharmacology, Pharmaceutical  Analysis and  Biopharmaceutics.

                         Thesis : Antidiabetic glycoside from Bambusa longispiculata.

                          Main research done : The hypoglycemic activity of the isolated glycoside from  Bambusa longispiculata was investigated in the animal model of rat. *The theoritical examination was held in 1983. The thesis was defended in 1985. The delay was due to political turmoil in the university.

1988- 1991 :        Department of Synthetic and Medicinal Chemistry, Faculty of  Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700,                                                      Japan. Degree obtained : Doctor of Philosophy (Ph.D.) (Professor Masatoshi Yamato)

                          Thesis : Asymmetric syntheses of Tertrahydroisoquinoline and   Tetrahydro-β- Carboline  alkaloids.

PROFESSIONAL EXPERIENCES

 

02/1985 – 11/1986:       Product Management Department, Square  Pharmaceuticals Ltd., Dhaka, Bangladesh.

                                       Position: Executive

12/1986 - 03/1992:        Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

                                      Position: Lecturer.

03/1992 – 03/1996:       Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

                                      Position: Assistant Professor.

03/1996 – 11/2000:       Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

                                       Position: Associate Professor.

11/2000– 2/2006  :        Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

                                      Position: Professor

03/2006- 02/2008  :       Department of Pharmacy, Southeast University, Dhaka, Bangladesh

                                       Position: Professor and Chairman.

03/2008-present     :      Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh

                                       Position: Professor

PUBLICATIONS

 

Research Articles

 

1. Yamato, M., Hashigaki, K., Ishikawa, S. and Qais, N.: Synthesis of chiral oxazolo [2,3-a] tetrahydroisoquinoline and its Asymmetric Alkylation. Synthesis of (S)-(-)- and (R)-(+)-Salsolidines: Tetrahedron Letter, 29, 6949-6950, 1988.

2.   Yamato, M., Hashigaki, K., Qais, N. and Ishikawa, S.: Asymmetric Synthesis of 1- alkyltetrahydroisoquinolines Using Chiral Oxazolo[2,3-a]tetrahydroisoquinolines: Tetrahedron, 46, 5909-5920, 1990.

3.   Hashigaki, K., Kan, K., Qais, N., Takeuchi, Y. and Yamato, M.: Asymmetric Syntheses of 1-Benzyltetrahydroisoquinolines Using Chiral Oxazolo[2,3-a]tetrahydroisoquinolines: Chem. Pharm. Bull., 39, 1126-1131, 1991.

4.   Qais, N., Nakao, N., Hashigaki, K., Takeuchi, Y. and Yamato, M.: Asymmetric Syntheses of 1-Alkyltetrahydro-b-carboline and a 9-thio Analogue: Chem. Pharm. Bull., 39, 3338-3340, 1991.

5.   Jabbar, A., Hossain, D., Qais, N. and Reza, M. S.: Antimicrobial activities of Alkaloids from Crataeva nurvala. The Dhaka University Journal of Biological Sciences, 4, 189-192, 1995.

6.   Qais, N., Rahman, M. M., Rashid, M. A. and Jabbar, A.: 5-Methoxy-7-hydroxyflavanone from Desmos chinensis. Fitoterapia, LXVII, 476, 1996.

7.   Qais, N., Rahman, M. M., Rashid, M. A., Koshino, H., Nagasawa, K. and Nakata, T.:  Antibacterial Flavonoids from Desmos chinensis. Fitoterapia, LXVII, 554-555, 1996.

8.   Qais, N., Rahman, M. M., Rashid M. A. and Jabbar, A.: Cytotoxic activity of Desmos    chinensis. The Dhaka University Journal of Biological Sciences, 5, 191-195, 1996.

9.   Qais, N., Rahman, M. M., Masum, M. A., Rashid, M. A and Jabbar, A.: Antibacterial and Antileishmanial activities of Desmos chinensis. Bangladesh Journal of Botany, 25, 155-158, 1996.

10. Qais, N., Rashid, M. A., Rouf, A. S. S. and Rahman, F.: Hypoglycemic activity of Bambusa     longispiculata. The Dhaka University Journal of Biological Sciences, 6, 65-72, 1997.

11. Qais, N., Mandal, M. R., Rashid, M. A., Jabbar, A., Koshino, H., Nagasawa, K. and Nakata, T: A Furanoid Labdane Diterpene from Potamogeton nodosus. Journal of Natural Products, 61, 156-157,

1998.

12. Huq, M.M., Jabbar A, Rashid M. A., Hasan C.M., Qais, N., Koshino, H. Suenaga, T., and  Nakata, T.: 1H- and 13C- NMR Assignments of Odorosside B. Fitoterapia, : I.XIX, 377-378, 1998.

13. Qais, N., Ahmed, R., Koshino, H., Suenaga, T., and Nakata, T.: Antibacterial activities of Crataeva nurvala. The Dhaka University Journal of Biological Sciences, 8, 191-194, 1999.

14. Rahman, M. M., Qais, N., Rashid, M. A.: A new C-benzylated chalcone from Desmos chinensis. Fitoterapia, 74, 511-514, 2003.

15. Qais, N. and Alimuzzaman, M.: Antinociceptive activity of an alcoholic extract of Tagetes erecta. Dhaka University Journal of Pharmaceutical Sciences, 2, 49-50, 2003.

16. Al-Mamun, M. E., Ali, M. H., Ahsan, M., Qais, N., and Chowdhury, R.: In vitro antibacterial activity of the crude extracts of Hedyotis corymbosa and Elaeocarpus robustus. Bangladesh J. Microbiol., 21,  42-43, 2004.

17. Jamaluddin, M. A. T., Qais, N., Ali, M. A., Howlader, M. A., Shams-Ud-Doha, K. M., and Apu, A. S.: Analgesic activity of extracts of the whole plant of Amaranthus spinosus. International Journal of Drug Development & Research, 3, 189-193, 2011.

18. Mahmud, Z. A., Bachar, S. C., and Qais, N.: Antihyperlipidemic activity of leaf and root extracts of Premna esculenta. Oriental Pharmacy and Experimental Medicine, 11, 263-270, 2011.

19. Mahmud, Z. A., Bachar, S. C., and Qais, N.: Evaluation of antinociceptive activity and brine shrimp lethality bioassay of roots of Leea macrophylla. International Journal of Pharmaceutical Sciences and Research, 2, 3230-3234, 2011.

20. Qais, N., Mahmud, Z. A., Karim, M. R., and Bachar, S. C.: Antinociceptive, antiinflammatory and sedating activities of leaf extracts of Premna esculenta. Journal of Pharmacy Research, 4, 3463-3465, 2011.

21. Khatun, F., Howlader, M. A., Apu, A. S., Bachar, S. C., and Qais, N.: Evaluation of analgesic and anti-diarroeal properties of the ethanolic extract of Crataeva nurvala leaves. International Journal of Pharmaceutical Sciences Review and Research, 12, 05-08, 2012.

22. Das, B. N. and Qais, N.: Analgesic activity of the rhizome extract of Alpinia nigra: Journal of Pharmacognosy and Herbal Formulations, 2, 29-32, 2012.

23. Mahmud, Z. A., Bachar, S. C., and Qais, N.: Antioxidant and hepatoprotective activity of ethanolic extracts of leaves of Premna esculenta against carbon tetrachloride induced liver damage in rats: Journal of Young Pharmacists, 4, 228-234, 2012.

24. Maria, S., Islam, F., Qais, N. and Hasan, C. M.: Isolation of Vomifoliol: A Megastigmane from leaves of Antidesma ghaesembilla: Asian Journal of Chemistry, 25, 3533-3534, 2013.

25. Doha, K. M. S. U., Mahmud, Z. A., Bacher, S. C., and Qais, N.: Antinociceptive, anti-inflammatory, antimicrobial and central nervous system depressant activities of ethanolic extract of leaves and roots of Gomphostemma parviflorum var. parviflorom wall. : Pharmacognosy Research, 5(4), 233-240, 2013.

26. Das, S. C., Qais, N., Kuddus, M. R., and Hasan, C. M.: Isolation and Characterization of (22R, 24S)-Stigmasta-5, 22, 25-trien-3β-ol from Clerodendrum viscosum Vent: Asian Journal of Chemistry, 25, 6447-6448, 2013.

27.  Rahman, E.T., Raihan, S.Z., Mahmud, Z.A. and Qais, N.; Analgesic activity of methanol extract and its  fractions of Streblus asper (Lour.) roots; World Journal of Pharmaceutical Research, 3(4), 18-24, 2014.

28. Shihan, M. H., Mahmud, Z. A., Qais, N., and Riaz, M.: Pharmacological evaluation of stem bark of Callicarpa arborea Roxb; Dhaka Univ. J. Pharm. Sci., 14(1), 111-116, 2015.

29. Mahmud, Z. A., Emran, T. B., Qais, N., Bachar S. C., Sarker, M., and Uddin, M. M. N.: Evaluation of  analgesic, anti-inflammatory, thrombolytic and hepatoprotective activities of   roots of Premna esculenta  (Roxb); J. Basic Clin. Physiol. Pharmacol. 27(1), 63-70, 2016.

30. Dasgupta, T., Chowdhury, R. N., Paul, K., and Qais, N.: Investigation of antioxidant, cytotoxic and  anthelmintic activities of yellow seeds of Bangladeshi Setaria italica; Indo American Journal of  Pharmaceutical Research, 6(3), 4870-4874, 2016.

31. Dasgupta, T., Poddar, S. K., Ganguly, A., and Qais, N.: Anti-inflammatory and neuropharmacological  activities of the seed extract of Setaria italica; Journal of Applied Pharmaceutical Science, 6(5), 193-197, 2016.

32. Dasgupta, T., Ganguly, A., Asaduzzaman, M., and Qais, N.: Evaluation of antimicrobial, hypoglycemic  and anti-diarrheal activities of Setaria italica; Dhaka Univ. J. Pharm. Sci., 15,  31-35, 2016.

33. Sultan, R. A., Kabir, M. S. H., Uddin, M. M. N., Uddin, M., Mahmud, Z. A. and Qais, N.:   Ethnopharmacological investigation of the aerial parts of Phragmites karka (Poeceae). J. Basic Clin. Physiol. Pharmacol., 28, 283-91, 2017.

34. Bhuiya, N. M. M. A., Hasan, M., Mahmud, Z. A., Qais, N., Kabir, M. S. H., Ahmed, F., and Uddin, M. M. N.: In vivo analgesic, antipyretic and anti-inflammatory potential of leaf extracts and fractions of Eria  javanica; J. Compliment. Integr. Med., 14 (1), 20160040, 2017.

35. Mahmud, Z. A., Bachar, S. C., Hasan, C. M., Emran, T. B., Qais, N., and Uddin, M. M. N.:  Phytochemical investigations and antioxidant potential of roots of Leea macrophylla (Roxb);  BMC Research Notes, 10:245, 2017.

36. Halder, S., Saqueeb, N., and Qais, N.: Antinociceptive and anthelmintic activities of the crude  methanolic extract and its fractions of leaves of the plant Leea aequata; Dhaka University Journal  of Pharmaceutical Sciences: accepted (2018).

37. Rahman, A., Naheed, N. I., Raka, S. C., Qais, N., and Momen, A. Z. M. R.: Ligand-Based Virtual  Screening, Consensus Molecular Docking, Multi-Target Analysis & Comprehensive ADMET Profiling For Identifying Novel Tyrosine Kinase Inhibitors Using Imatinib As A Template; PeerJ. : submitted  (2018).

International Symposium Papers

38. Yamato, M., Hashigaki, K., Ishikawa, S. and Qais, N. (1988): Stereoselective Synthesis of 1-Substituted Tetrahydroisoquinoline using Isochromans.  Paper was published at the 14th Symposium on the Progress in Organic Reactions and Syntheses held at Sendai, Japan, November, 1988, 181-185 (in Japanese, abstract in English).

39. Nakata, T., Matskura, H., Jian, D., Qais, N., Nagashima, H., Nakagawa, T. and Oishi, T. (1993): Synthetic studies on Mycalamide A and related compounds.  Paper was published at the 35th Symposium on the Chemistry of Natural Products held at Kyoto, Japan, October, 1993, 598-605 (in Japanese, abstract in English).

 

Review Articles

 

40. Qais, N.: Stereoselective Synthesis of Tetrahydroisoquinolines; Bangladesh Pharmaceutical Journal, 11,  23-26, 1993.

41. Qais, N., Jahan, S. and Shajib, M. S.: A Review on Anti-diabetic Plants; Dhaka University Journal of  Pharmaceutical Sciences, 17(1), 139-152, 2018.

 

Books in the form of Monographs

 

42. Pharmacological potential investigation of Setaria italica: Evaluation of pharmacological activities of  Setaria italica. By Dasgupta, T., Asaduzzaman, M., and Qais, N.: Lap Lambert Academic  Publishing, Germany (April 12, 2012).

43. Ethnopharmacological investigation of Cayratia  trifolia: Biological screening of whole plant parts (root, stem and leaves) of Cayratia trifolia. By Islam, M. Z., Qais, N. and Raihan, S. Z.: Lap Lambert  Academic Publishing, Germany (May 21, 2012).

44. Pharmacological Investigations of Premna esculenta (Roxb) (Verbenaceae): Biochemical, Pharmacological and toxicological aspects. By Mahmud, Z. A., Islam, M. A., and Qais, N.  Lap Lambert Academic Publishing, Germany (October 11, 2012).

ABSTRACTS OF THE DOCTORAL RESEARCH :

A new and facile method for the synthesis of 1-alkyl, and 1-aryltetrahydroisoquinolines in enantiomerically pure form was developed via the diastereoselective alkylation of chiral intermediate, (3R, 10bS)-3-Phenyl-2,3,5,6-tetrahydro-10bH-oxazolo[2,3-a]isoquinoline and its 8,9-Dimethoxy analogue with Grignard reagents followed by removal of chiral moiety by hydrogenolysis on Pd-C in acidic EtOH. The reaction of the chiral intermediate with benzylmagnesium halides proceeded with exceptionally low diastereoselectivity. The chiral intermediate was then reacted with another benzylating agent namely benzyltriisopropoxytitanium compounds and we got 60-90% de. The diastereomers were separated by column chromatography. The reaction of the chiral intermediate with benzylmagnesium halide gave (S)-isomer whereas the reaction of the same chiral intermediate with benzyltriisopropoxytitanium compounds gave (R)-isomer as the main product.

The same principle was also extended towards the asymmetric synthesis of 1-alkyltetrahydro-b-carboline and its 9-thio analogue. Few simple Isoquinoline and Tetrahydro-b-carboline alkaloids, namely (S)-(-)- and (R)-(+)-Salsolidines, (S)-Homolaudanosine, (S)-Cryptostiline II, (S)-Tetrahydroharman, (S)-norarmepavine and (S)-Tetrahydropapaverine were synthesized.

 

02/1993 – 09/1993:   Institute of Physical and Chemical Research (RIKEN), Hirosawa-2-1,

                                  Wako-shi, Saitama 351-01, Japan

                                  Research studies: Post-doctoral Research Studies (Dr. Tadashi Nakata)

                                  Research involved: The asymmetric synthesis of the left half of Mycalamide A,

                                   a complex antiviral and anticancer natural product.

 

 

RESEARCH EXPERIENCES

I have 21 years of research experience in asymmetric synthesis with the art of multi-step synthesis, isolation, purification, structure determination and pharmacological evaluation of plant products and possess technical skills in chromatographic techniques (CC, TLC and HPLC) and  spectroscopic analysis (IR, NMR and Mass).

Knowledge of asymmetric synthesis with the art of multi-step synthesis includes

1. Synthesis of 1-alkyl,1-aryl and 1-bezyltetrahydroisoquinolines in enantiomerically pure form  via the alkylation of chiral intermediate,(3R,10bS)-3-Phenyl-2,3,5,6-tetrahydro-10bH-oxazolo[2,3-a]isoquinoline and its 8,9-Dimethoxy analogue with Grignard reagents followed by removal of chiral moiety by hydrogenolysis on Pd-C in acidic EtOH. Experiences in the  asymmetric synthesis of 1-alkyltetrahydro-b-carboline and its 9-thio analogue.

2. Preparations of isochromans and their application in the synthesis of 2- (2-Haloethyl)benzaldehyde and its 4,5-Dimethoxy analogue needed for chiral intermediate synthesis from (R)- or (S)-Phenylglycinol.     

3. Preparations of various Grignard reagents from alkyl, aryl, benzyl and substituted benzyl halides; in the preparations of benzyl and substituted benzyltriisopropoxytitanium compounds from benzyl and substituted benzylmagnesium chlorides and chlorotitanium triisopropoxide; and in preparation of alkyl halides starting from aldehydes and carboxylic acids including their synthesis.

4. Practical knowledge on lithiation, Vilsmeier-Haack reaction, Eschweiler-Clarke reaction, Birch reduction, and hydrogenation using Pd-C.

SCHOLARSHIP / FELLOWSHIP

 

1. Bangladesh Government scholarships awarded during college and university student life.

2. Japanese Government Scholarship (Monbusho) awarded for pursuing Ph.D. research at 

    Okayama University.

3. Science and Technology Agency (STA) fellowship offered by the Research Development

    Corporation of Japan (JRDC) for Post-doctoral research at RIKEN.

 

M. PHARM. THESIS SUPERVISED

Already supervised twenty research students who submitted their dissertations on chemical and biological studies of medicinal plants as a part of their Master of Pharmacy degree.

MEMBER OF LEARNED BODIES

1. Member, Editorial Board, Bangladesh Pharmaceutical Journal.

2. Member, Bangladesh Pharmaceutical Society.

 

PERSONAL INFORMATIONS

Date of birth : 1st October,1960

Place of birth : Rajshahi, Bangladesh

Civil status : Married, Sex : Male, No. of Children : 2

Language known : Bengali (mother tongue),

English (both spoken and written) and Japanese (only spoken)

Computer knowledge : Microsoft word, Chem Draw

 

Mailing address :

Professor Nazmul Qais

Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh,

Email : nqais@du.ac.bd

Cell: +880-1714417750