Profile of Mohammad Kaisarul Islam

... Name Mohammad Kaisarul Islam
Designation Lecturer
Last Degree PhD in Pharmaceutical Sciences, King's College London, UK
   

PhD in Pharmaceutical Chemistry, King’s College London, UK, 2016.
Masters in Pharmaceutical Chemistry, University of Dhaka, Bangladesh, 2006.
B. Pharm (Hons.), University of Dhaka, Bangladesh, 2005.

Post-Doctoral Research Assistantship (Oct’16-Aug’17)

Project PI: Dr Daniele Castagnolo, Lecturer in Pharmaceutical Chemistry, King’s College London, London, UK.

Funding: EPSRC.

Project Summary: Synthesis of novel siderophores and siderophore conjugated antibiotics for gram-ve bacteria.

Responsibilities:

  • Perform experimental work including the design and synthesis of target molecules
  • Supervision and scientific leadership of chemistry associates including establishing work plans, monitoring progress, further education, training, and development of team members (i.e., MSc/MPharm students).
  • Provide leadership in all aspects of laboratory Health, Safety and Environmental protection.
  • Active participation in the internal and external scientific communities through presentations, publication, and networking across the chemistry community.
  • Contribute to maintaining state of the art skills, facilities, and infrastructure within drug design and discovery chemistry through the evaluation and implementation of new methods, techniques, reactions and concepts.

Skills Earned to-date:  

  • Gained knowledge in medicinal chemistry, organic synthesis, purification techniques and various biophysical and biological assays.
  • Experience in characterisation methods including LC-MS, NMR, UV and IR spectroscopy.
  • Earned good skills in FRET melting assay, CD spectroscopy, cytotoxicity assay and moderate skills in RT-PCR and gel electrophoresis.

The data generated during my PhD studies have been published in two peer reviewed journals (details are in publication section) and presented at several international conferences including the AACR Annual Meetings and the Nucleic Acid Forum as poster and oral presentation.

1. I also got training to work on Phytochemical and Biological investigation of plant materials and natural product chemistry. I have skills on various –

  • extraction techniques,
  • partitioning techniques,
  • TLC and column chromatography,
  • cytotoxicity analysis using brine shrimp and antimicrobial analysis.

2. Moreover, I have good knowledge on pharmaceutical analysis and analytical techniques, like Karl-Fischer test, UV analysis, hardness test, friability analysis, dissolution and disintegration analysis, pH analysis, solubility test, which are routinely employed in the quality control and quality assurance of any pharmaceutical product.

Research Article:

  1. Islam MK, Jackson PJM, Thurston DE, Rahman KM. Methylene-linked bis-phenylbenzimidazoles - a new scaffold to target telomeric DNA/RNA hybrid duplex. Org Biomol Chem. 2018 Mar 2. DOI: 10.1039/c7ob02709e. [Epub ahead of print]
  2. Mohammad K. Islam, Paul J. M. Jackson, Khondaker M. Rahman, David E. Thurston. Recent advances in targeting the telomeric G-quadruplex DNA sequence with small molecules as a strategy for anticancer therapies. Future Med Chem. 8(11), 1259-1290, 2016. DOI: 10.4155/fmc-2015-0017
  3. Mia Mohammad Dulal, Md Kaisarul Islam, Abu Asad Chowdhury, Jakir Ahmed Chowdhury. Prevention of cap-locking of syrup product by treating the manufacturing process of sugar syrup with citric acid monohydrate. Bangladesh Pharmaceutical Journal 19(2): 190-196, 2016. DOI: 10.3329/bpj.v19i2.292792.
  4. Mohammad Kaisarul Islam, Md. Hossain Sohrab and Abdul Jabbar. Caffeine and p-anaisaldehyde from the fruits of Enterolobium saman Prain. Int. J. Pharm. Sci and Res. 3(1). 168-170 (2012). DOI: 10.13040/IJPSR.0975-8232.3(1).168-70
  5. Mohammad Kaisarul Islam and Khondaker Ashakin. Antimicrobial screening and brine shrimp lethality bioassay of Tinospora cordifolia (Fam: Menispermeaceae). Int. J. Pharm. Sci and Res. 2(11). 3091-3095 (2011). DOI: 10.13040/IJPSR.0975-8232.2(12).3091-95
  6. Md. Mominur Rahman, Jakir Ahmed Chowdhury, Razibul Habib, Barun Kanti Saha, A.D.M Salauddin and Mohammad Kaisarul Islam. Anti-inflammatory, anti-arthritic and analgesic activity of the alcoholic extracts of the plant Urginea indica Kunth. Int. J. Pharm. Sci and Res. 2(9). 2320-2324 (2011). DOI: 10.13040/IJPSR.0975-8232.2(11).2915-19
  7. Md Ruhul Amin, Moynul Hasan, Abdullah Al Masud, Md Hanif uddin, Md Hasanuzzaman and Mohammad Kaisarul Islam. Validated UV spectrophotometric method for estimation of Dutasteride in tablet dosage form. Pharmacie Globale: International Journal of Comprehensive Pharmacy (IJCP). 1(4). 1-3 (2011).
  8. Abdullah Al Masud, Md. Shamsul Arefeen, Mohammad Kaisarul Islam, Moynul Hasan. Development and validation of a RP-HPLC method for the estimation of Levetiracetam in bulk and pharmaceutical formulation. Journal of Chemical and Pharmaceutical Research. 3(1). 324-329 (2011). ISSN: 0975-7384
  9. Al-Mamun R, Hamid A, Islam MK, Chowdhury JA and Zafrul Azam ATM. Lipid lowering activity and free radical scavenging effect of Cinnamomum tamala (Fam: Lauraceae). International Journal of Natural Sciences. 1(4). 93-96 (2011). DOI:10.3329/ijns.v1i4.9735
  10. Jakir Ahmed Chowdhury, Sheikh Tasnim Jahan, Md. Masud Morshed, Jewel Mallick, Aninda Kumar Nath, Md Zia Uddin, Mycal Dutta, M. Kaisarul Islam, Md. Hassan Kawsar. Development and evaluation of diclofenac sodium loaded alginate cross-linking beads. Bangladesh Pharmaceutical Journal. 14 (1), 41-48 (2011). ISSN: 0301-4606
  11. M. K. Islam, J. A. Chowdhury, I. Z. Eti. Biological Activity study on a Malvaceae plant: Bombax ceiba. Journal of Scientific Research. 3 (2), 445-450 (2011). DOI: http://dx.doi.org/10.3329/jsr.v3i2.5162
  12. Mohammad Kaisarul Islam, Qamer Ibn Sharif, Neher Sultana Sherin, Jakir Ahmed Chowdhury. In vitro evaluation of Theophylline SR dosage form available on the Bangladeshi drug market. Journal of Dhaka International University. 2(1). 143-147 (2011).
  13. Mohammad Kaisarul Islam, Moynul Hasan, Nasrin Akhter, Jakir Ahmed Chowdhury. Quantitative and qualitative estimation of marketed paracetamol products in Bangladesh: Solid dosage forms. Journal of Dhaka International University. 2(1). 148-153 (2011).
  14. M. Kaisarul Islam, Israt Zahan Eti, Jakir Ahmed Chowdhury. Phytochemical and antimicrobial works on Oroxylum indicum Linn. Iranian Journal of Pharmacology and Therapeutic). 9(1). 25-28 (2010). (Online: http://en.journals.sid.ir/ViewPaper.aspx?ID=181098)
  15. Mohammad Borhan Uddin, Jakir Ahmed Chowdhury, Kazi Rashidul Azam, M. Kaisarul Islam. Investigation of the effects of different physicochemical parameters on in vitro release kinetics of theophylline from Eudragit NE 30 and Eudragit RS 30D matrix tablets. J. Pharm. Sci. & Res. 2(4). 240-246 (2010). ISSN: 0975-1459 (Online: http://www.jpsr.pharmainfo.in/issue.php?page=8)
  16. Rakib Al-Mamun, Abdul Hamid, Mohammad Kaisarul Islam, Jakir Ahmed Chowdhury. Cytotoxic and thrombolytic activity of leaves extract of Parthenium hysterophorus (Fam: Asteraceae). Bangladesh Pharmaceutical Journal. 13 (2), 51-54 (2010). ISSN: 0301-4606
  17. Sheikh Tasnim Jahan, Md. Saiful Islam, Sams Mohammad Anowar Sadat, Mohammad Kaisarul Islam, Jakir Ahmed Chowdhury. Surface morphology and release behaviors of theophylline loaded sodium alginate gel beads. Bangladesh Pharmaceutical Journal. 13 (2), 41-46 (2010). ISSN: 0301-4606
  18. Israt Nimmi, Bilquis Romana, M. Kaisarul Islam, Jakir Ahmed Chowdhury, Mia Mohammad Dulal. Sectility test on three marketed drugs act on β-receptor. Bangladesh Pharmaceutical Journal. 13 (1), 71-73 (2010). ISSN: 0301-4606
  19. Ishtiaq Ahmed, Muhammad Rashedul Islam, Jakir Ahmed Chowdhury, Mohammad Kaisarul Islam, Md. Habibur Rahman. In vitro release kinetics study of naproxen from swellable hydrophilic matrix tablets. Bangladesh Pharmaceutical Journal. 13 (1), 18-22 (2010). ISSN: 0301-4606
  20. Md. Saiful Islam, Ashfacur Rahman, Mohammad Kaisarul Islam, Jakir Ahmed Chowdhury and Reza-ul Jalil. Preparation and characterization of polyvinyl acetate (Kollidon® SR) microspheres containing diclofenac sodium II: Effect of core loading. Dhaka Univ. J. Pharm. Sci. 8(2), 117-122 (2009). ISSN: 1816-1839
  21. Mohammad Kaisarul Islam, Mohammad Borhan Uddin, Jakir Ahmed Chowdhury. Quantitative and qualitative estimation of marketed paracetamol products in Bangladesh: I. Liquid Dosage Forms. Journal of Dhaka International University. 1(1). 185-189 (2009).
  22. Chowdhury J. A., Islam M.S., Asifuzzaman Sk., Islam M.K. Antibacterial and cytotoxic activity screening of leaf extracts of Vitex negundo (Fam: Verbenaceae). J. Pharm. Sci. & Res. 1(4). 103-108 (2009). ISSN: 0975-1459
  23. M. K. Islam, I. Z. Eti, and J. A. Chowdhury. Cytotoxic studies on two Meliaceae plants: Chukrasia tabularis and Aglaia roxburghiana. Journal of Scientific Research. 1 (2), 399-403 (2009). ISSN: 2070-0245

Conference Poster Presentations:

  1. Biphenylene and bipyridine connected benzofuran compounds as novel regulators of k-Ras transcription; 17/04/16, AACR Annual Meeting 2016, New Orleans, USA. DOI: 10.1158/1538-7445.AM2016-2914 Published July 2016
  2. Identification and chemical variation of novel telomerase-targeting scaffolds to provide lead structures for development as potential anticancer agents; 10/04/13, AACR Annual Meeting 2013, Washington DC, USA.
  3. Targeting key DNA/RNA heteroduplex of telomerase by small-molecule ligands; 05/07/13, Nucleic Acid Forum, Royal Society of Chemistry, UK.
  4. Targeting Key DNA/RNA Heteroduplex of Telomerase by Small-molecule Ligands; October 19-23, 2013; AACR-NCI-EORTC International Conference 2013, Boston, USA. DOI: 10.1158/1535-7163.TARG-13-B204 Published November 2013
  5. Targeting telomeric DNA/RNA heteroduplex by small-molecule ligands; 04/05/14, Institute of Pharmaceutical Science Research Symposium, King’s College London, UK.

Oral Presentations:

  1. Targeting Telomeric DNA/RNA Heteroduplex with Small-Molecule Ligands; 04/07/14, Nucleic Acid Forum, Royal Society of Chemistry, UK.
  2. Design and synthesis of a small molecule scaffold targeting telomeric DNA/RNA heteroduplex in cancer cells; 26/05/15, IPS Research Symposium, King’s College London, UK.

I enjoy teaching Organic Chemistry, Pharmaceutical Analysis (i.e., UV-Vis Spectroscopy, IR Spectroscopy, NMR, and Mass Spectroscopy), Medicinal Chemistry, Drug Design & Discovery and Pharmacognosy. Besides my regular courses, I taught Bio-Statistics, Inorganic Chemistry, Pharmaceutical Marketing and Management, QC & Pharmaceutical Validation at undergraduate and post-graduate level. Details of my teaching experience are listed below:

S/N Organisation Position From - To
1 University of Dhaka, Bangladesh Lecturer in Pharmaceutical Chemistry 20/01/11 to 01/10/11 and 10/09/17 to Present
2 King’s College London, UK Postdoctoral Research Assistant 03/10/16 to 31/03/17 (Full time), 01/04/17 to 25/08/17 (volunteering)
3 Jagannath University, Bangladesh

Lecturer in Pharmacy

03/05/10 to 19/01/11
4 The University of Asia Pacific, Bangladesh Assistant Professor in Pharmacy 14/10/09 to 19/04/10
5 The University of Asia Pacific, Bangladesh Lecturer in Pharmacy 18/04/06 to 13/10/09
6 King’s College London, UK Lab Demonstrator    (Part-time) April 2012 to December 2015
7 King’s College London, UK OSCE Invigilator      (Part-time) April 2012 to December 2016

Administrative Exposure:

  1. Institute          : The University of Asia Pacific, Bangladesh

            Designation   : Head, Department of Pharmacy

            Duration         : 02/02/10 to 19/04/10

            Duties             : I was responsible and accountable for - a. setting and advancing the academic strategy in line with Department and University strategic plans and direction, b. developing and supporting proper structures of management, decision-making and communication among staff and students, c. fulfilling of the University´s responsibilities concerning students in respect of their admission, instruction, progress and examination, d. refreshing and developing new courses.

  1. Institute          : The University of Asia Pacific, Bangladesh

            Designation   : Coordinator (MS Pharm Tech)

            Duration         : 22/04/08 to 18/04/10

            Duties             : I was responsible for a. creating dynamic and forward-looking research environment for academicians and students, b. course distribution and planning, c. pastoral caring, d. preparing budget and procuring new instruments and reagents.

  1. Institute          : The University of Asia Pacific, Bangladesh

            Designation   : Assistant to Head (Undergraduate program)

            Duration         : 22/04/09 to 01/02/10

            Duties : I was responsible to help in coordinating undergraduate program.

1. Commonwealth Scholarship in the UK (2011-2015)
2. Scholarship by Govt. of Bangladesh at undergraduate level (1998-2002)
3. Scholarship from Dhaka Education Board based on results in SSC examination (1996-1998)
4. Scholarship from BTMC based on results in class-VIII (1993-1996)

Research Interest:

1. Medicinal Chemistry, Small molecule/drug design and lead optimization.

2. Natural Product Chemistry (phytiochemicals isolation, characterization and bioactivity analysis).

Future Plan-Telomere targeted anticancer drug discovery

Discovering an anticancer drug is one of my long time goal. Telomere and telomerase targeted drug discovery is a broad area of research, which can be selective and most efficient way to kill cancer. Number of published article have claimed about 85% cancer cells are experiencing up-regulation of telomerase, a reverse transcriptase enzyme responsible for elongation of telomeric end of chromosome and help the cancer cell to go for further division. Upregulation of the level hTERT and hTR is linked to human cancer. In contrast to telomerase activity, where an RNA template is used for the synthesis of new telomeric DNA, the alternative lengthening of telomeres (ALT) mechanism involves the elongation of the telomeric DNA sequence from a DNA template via a homologous recombination protein, that ultimately lead to tumour growth.

Anticancer approaches directed at telomerase inhibition can be varied and possible methods include stabilizing telomeric G-quadruplex structures, RNA interference (RNA) of the hTERT catalytic subunit and stabilizing DNA/RNA hybrid duplex structures towards the large protein surface of the telomerase enzyme.

Different research groups are mostly working to stabilize the G-quadruplex structures as an anticancer strategy either in promoter regional quadruplex structure or telomeric quadruplex. However, targeting hTERT, hTR or telomeric DNA/RNA hybrid still remains unexplored. I, personally, did some works on telomeric DNA/RNA hybrid targeted drug design and development during my PhD research. In 1999, Prof. Jonathan B. Chaires and his research group reported some know structures (e.g., ethidium bromide, coralyne chloride and DAPI) with minimal effectivity towards the hybrid. In 2010, Prof. Wheelhouse and his team reported a diaryl substituent and pyrimidine analogue with a greater preference for the hybrid duplex compared to the duplex DNA; however it was not reported for the telomeric DNA/RNA hybrid sequence. In 2001, two naphthalene-type molecules were reported as highly selective telomerase inhibitors, where BIBR1532 showed competitive binding to the active site of hTERT but it did not block the template copying site for the telomere elongation process. PARP inhibitor, Olaparib, has approved by FDA as a targeted therapy of cancers with hereditary BRCA1 or BRCA2 mutations (including ovarian, breast, and prostate cancers), which is acting by inhibiting Tankyrase-1. Thus it is clear that there are not many outcome from this research field, however, it is well know that telomerase is over expressed in every cancer cells and lead to propagation of tumour growth and causes cancer related morbidity.

My future plan is to employ my medicinal chemistry skills and knowledge to design new chemical scaffold to target hTERT and/or hTR expression and thus minimizing the catalytic nactivity of telomerase. Many studies have focused on the role of transcriptional control of hTERT expression or on phosphorylation-induced increases in hTERT activity. Protein kinase Ca and PkB can phosphorylate hTERT. Mutations within the core promoter region of hTERT are common, and these may increase hTERT transcriptional activity by creating new consensus binding motifs for ETS transcription factors. hTERT promoter mutations are most common in malignancies like bladder carcinoma, liposarcomas (e.g., fat cells of deep soft tissue), hepatocellular carcinoma, squamous cell carcinoma (e.g., tongue), medulloblastomas (i.e., malignant primary brain tumour) and glioblastoma (aggressive malignant primary brain tumour). Another mechanism of up-regulation is translocation of the hTERT gene to an immunoglobulin gene or other loci in B-cell neoplasms, which presumably contributes to the increased hTERT transcription and telomerase activity observed in these tumours. The human telomerase catalytic subunit (hTERT) and the RNA template molecule (hTR) are both present in very low amount in normal cells, and it is likely that the expression of both must be increased in order to express sufficient telomerase to prevent telomere shortening in cancer cells. Thus if we can control the expression of hTERT and hTR, cancer cell cycle also could be controlled and forced to apoptosis.

I enjoy teaching Organic Chemistry, Pharmaceutical Analysis (i.e., UV-Vis Spectroscopy, IR Spectroscopy, NMR, and Mass Spectroscopy), Medicinal Chemistry, Drug Design & Discovery and Pharmacognosy. Besides my regular courses, I taught Bio-Statistics, Inorganic Chemistry, Pharmaceutical Marketing and Management, QC & Pharmaceutical Validation at undergraduate and post-graduate level. Details of my teaching experience are listed below:

S/N Organisation Position From - To
1 University of Dhaka, Bangladesh Lecturer in Pharmaceutical Chemistry 20/01/11 to 01/10/11 and 10/09/17 to Present
2 King’s College London, UK Postdoctoral Research Assistant 03/10/16 to 31/03/17 (Full time), 01/04/17 to 25/08/17 (volunteering)
3 Jagannath University, Bangladesh

Lecturer in Pharmacy

03/05/10 to 19/01/11
4 The University of Asia Pacific, Bangladesh Assistant Professor in Pharmacy 14/10/09 to 19/04/10
5 The University of Asia Pacific, Bangladesh Lecturer in Pharmacy 18/04/06 to 13/10/09
6 King’s College London, UK Lab Demonstrator    (Part-time) April 2012 to December 2015
7 King’s College London, UK OSCE Invigilator      (Part-time) April 2012 to December 2016

Administrative Exposure:

  1. Institute          : The University of Asia Pacific, Bangladesh

            Designation   : Head, Department of Pharmacy

            Duration         : 02/02/10 to 19/04/10

            Duties             : I was responsible and accountable for - a. setting and advancing the academic strategy in line with Department and University strategic plans and direction, b. developing and supporting proper structures of management, decision-making and communication among staff and students, c. fulfilling of the University´s responsibilities concerning students in respect of their admission, instruction, progress and examination, d. refreshing and developing new courses.

  1. Institute          : The University of Asia Pacific, Bangladesh

            Designation   : Coordinator (MS Pharm Tech)

            Duration         : 22/04/08 to 18/04/10

            Duties             : I was responsible for a. creating dynamic and forward-looking research environment for academicians and students, b. course distribution and planning, c. pastoral caring, d. preparing budget and procuring new instruments and reagents.

  1. Institute          : The University of Asia Pacific, Bangladesh

            Designation   : Assistant to Head (Undergraduate program)

            Duration         : 22/04/09 to 01/02/10

            Duties : I was responsible to help in coordinating undergraduate program.

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